Measured Dosage pump No Guessing How Much to Apply Clinical Strength Liposome Technology Natural, Paraben FreeDiscussion: AllVia Bio-estro cream contains an 80/20 combination of two natural estrogens intended to help support women's optimal balance. Each full press of the pump provides approximately 1 mg of natural Estriol USP and 0.25 mg natural Estradiol USP. Bio-Estro is formulated to contain 24 mg of estriol and 6 mg of estradiol per ounce.